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KMID : 0369819930230010051
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Jorunal of Korean Pharmaceutical Sciences
1993 Volume.23 No. 1 p.51 ~ p.53
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Evaluation of Physical Properties of Mucosal Adhesive Tablets ( I ) : Adhesive Force
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박광신/Park KS
정비환/차봉진/권종원/Chung BH/Cha BJ/Kwon JW
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Abstract
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Mucoadhesive tablets containing hydroxypropylcellulose-H (HPC) and carbopol 934 (CP) were prepared from direct compression. Their adhesive forces and water absorptions were investigated by using mouse peritoneal membrane and 1.5% agar plate, respectively. Adhesive force was significantly improved with increasing CP concentration, but was not affected by compression force and addition of disintegrants. And adhesive force to mouse peritioneal membrane was increased as fixing time increased. In conclusion, adequate adhesive force can be obtained by control of CP/HPC ratio and fixing time.
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KEYWORD
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Adhesive tablet, HPC, CP, adhesive force, Water absorption, Compression force, Fixing time
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